Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10 
 
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g

Top Medical Research Studies

9
Inulin improves liver health
We explored how inulin, a prebiotic, can positively influence liver health, particularly in cases of nonalcoholic fatty liver disease (NAFLD). The study involved rats fed a high-sucrose diet, revealing that those receiving inulin showed less liver fat buildup and inflammation compared to a control group. It appeared that inulin helped restore key liver and fat metabolism markers, which play vital roles in managing fat accumulation in the liver.

Moreover, we observed that inulin supplementation improved the gut barrier function. By increasing the levels of certain proteins that help keep our gut intact, inulin seems to help prevent harmful substances from entering the body. This represents a significant advance in understanding not just the direct impact of inulin, but how gut health interconnects with liver conditions.

Our analyses of gut bacteria also yielded encouraging results. Inulin intake led to a rise in beneficial bacteria linked to short-chain fatty acid production, while harmful bacteria were decreased. This shift suggests that inulin may help create a more balanced gut environment, which is crucial for maintaining overall health. In addition to these findings, we noted changes in tryptophan metabolism that may further explain the benefits of inulin. Overall, we feel that inulin holds promise as a dietary intervention for preventing and managing NAFLD in the future.
Read More
8
Inulin's impact on fatty liver
We studied the effects of inulin, a type of dietary fiber, on non-alcoholic fatty liver disease (NAFLD) using a high-fat diet-induced mouse model. By treating these mice with inulin, we closely examined changes in their liver health through various tests, including liver enzyme levels and fat accumulation.

Our findings indicate that inulin significantly alleviates symptoms of NAFLD. The treatment led to improvements in liver structure and reduced cholesterol levels within the liver. Through a detailed serum metabolomics study, we identified a total of 347 metabolites that varied between the model and control groups, of which 139 showed changes in response to inulin treatment.

Notably, we pinpointed 48 specific metabolites, including phosphatidylserine and L-carnitine, that appeared to be influenced by inulin. These metabolites are linked to crucial metabolic pathways involved in fat metabolism. Overall, our research suggests that inulin plays a considerable role in mitigating NAFLD symptoms, possibly by modulating various metabolic processes and offering new insights into potential therapies for this liver condition.
Read More
9
Inulin's therapeutic effects on fibrosis
We focused on understanding how inulin neoseries-type fructan, specifically OJP-W2, derived from Ophiopogonis Radix, impacts liver fibrosis. The findings show that OJP-W2 has a molecular weight of 5.76 kDa and consists of glucose and fructose in a ratio of approximately 1 to 30.87.

The structure of OJP-W2 reveals a mainly linear arrangement with β-D-fructosyl units linked in a specific pattern. This unique configuration is believed to play a vital role in its therapeutic benefits.

Our research highlights OJP-W2's significant hepatoprotective effect, which includes reducing collagen buildup in the liver and modulating crucial signaling pathways related to inflammation and apoptosis. We observed a decrease in various inflammatory markers, showcasing the potential of inulin in supporting liver health and combating fibrosis.

Overall, these results offer valuable insights into the advantages of utilizing inulin from Ophiopogonis Radix for liver disease management. By expanding our understanding of fructans, we pave the way for new therapeutic strategies targeting liver fibrosis and related conditions.
Read More

Most Useful Reviews

7.5
Enhances immunity
1 people found this helpful
I purchased Inulin for regular bowel movements, and it's a good prebiotic with several noted benefits. The powder is pleasant to drink, with a sweet taste. It may increase immunity, cleanse liver cells, and enhance digestion, allowing better absorption of vitamins and minerals. I recommend it.
Read More
9
Promotes digestion
It certainly works. One of my favourite dietary supplements. My intestines function like clockwork. It can be used independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits; do not doubt its effectiveness.
Read More
9
Effective supplement
It definitely works. One of my favourite dietary supplements, my intestines function like clockwork. It can be taken independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits, so do not doubt its efficacy.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
  • All Researches
9
Inulin's therapeutic effects on fibrosis
We focused on understanding how inulin neoseries-type fructan, specifically OJP-W2, derived from Ophiopogonis Radix, impacts liver fibrosis. The findings show that OJP-W2 has a molecular weight of 5.76 kDa and consists of glucose and fructose in a ratio of approximately 1 to 30.87.

The structure of OJP-W2 reveals a mainly linear arrangement with β-D-fructosyl units linked in a specific pattern. This unique configuration is believed to play a vital role in its therapeutic benefits.

Our research highlights OJP-W2's significant hepatoprotective effect, which includes reducing collagen buildup in the liver and modulating crucial signaling pathways related to inflammation and apoptosis. We observed a decrease in various inflammatory markers, showcasing the potential of inulin in supporting liver health and combating fibrosis.

Overall, these results offer valuable insights into the advantages of utilizing inulin from Ophiopogonis Radix for liver disease management. By expanding our understanding of fructans, we pave the way for new therapeutic strategies targeting liver fibrosis and related conditions.
Read More
We investigated how inulin can help fight metabolic dysfunction-associated fatty liver disease (MAFLD). Through an experiment featuring hens fed a high-fat diet, we noticed that inulin significantly influenced the gut microbiota, particularly the Megamonas genus, which seems to have a protective effect against liver fat accumulation.

By giving the hens a specific bacterium known as M. funiformis CML154, we found that it improved their liver health. This treatment not only changed the way their liver functioned but also boosted levels of beneficial propionate in the gut. Propionate appears to activate key processes in the body that help break down fat and prevent the creation of new fat.

Overall, our findings indicate that inulin, when paired with M. funiformis CML154, could be considered a promising approach for preventing or treating MAFLD. This opens up exciting avenues for using probiotics in liver health strategies.
Read More
9
Inulin improves liver health mechanisms
We examined how dietary inulin, a type of soluble fiber, influences liver disease, particularly non-alcoholic steatohepatitis (NASH), in mice. Our study revealed that inulin is more effective than insoluble fiber in reducing symptoms of NASH, such as liver fat accumulation and inflammation.

By using advanced techniques, we traced how the gut bacteria metabolized inulin, leading us to discover that a specific gut bacterium, Parabacteroides distasonis, thrived on this fiber. This bacteria converted inulin into pentadecanoic acid, a fatty acid with beneficial properties. Notably, both the bacteria and the fatty acid offered protection against NASH symptoms, improving overall liver health.

Our findings suggest that dietary fiber like inulin can significantly benefit liver health by promoting the growth of helpful gut bacteria and their metabolites. This adds an exciting dimension to how we can use dietary interventions to combat liver diseases.
Read More
9
Inulin improves liver health
We explored how inulin, a prebiotic, can positively influence liver health, particularly in cases of nonalcoholic fatty liver disease (NAFLD). The study involved rats fed a high-sucrose diet, revealing that those receiving inulin showed less liver fat buildup and inflammation compared to a control group. It appeared that inulin helped restore key liver and fat metabolism markers, which play vital roles in managing fat accumulation in the liver.

Moreover, we observed that inulin supplementation improved the gut barrier function. By increasing the levels of certain proteins that help keep our gut intact, inulin seems to help prevent harmful substances from entering the body. This represents a significant advance in understanding not just the direct impact of inulin, but how gut health interconnects with liver conditions.

Our analyses of gut bacteria also yielded encouraging results. Inulin intake led to a rise in beneficial bacteria linked to short-chain fatty acid production, while harmful bacteria were decreased. This shift suggests that inulin may help create a more balanced gut environment, which is crucial for maintaining overall health. In addition to these findings, we noted changes in tryptophan metabolism that may further explain the benefits of inulin. Overall, we feel that inulin holds promise as a dietary intervention for preventing and managing NAFLD in the future.
Read More
8
Inulin aids liver health research
We explored the effects of combining a probiotic strain, L47, with inulin on liver health, particularly in relation to liver disease, in a study involving weaned piglets. This experiment involved 28 piglets, divided into four groups: a control group, a group receiving just the probiotic and inulin, a group challenged with harmful bacteria, and a group receiving both the probiotic and harmful bacteria.

Our findings revealed that the combination of L47 and inulin, referred to as CLN, significantly alleviated the inflammation in the colon caused by bacterial infection. We noted improvements like deeper colonic crypts, increased levels of beneficial compounds, and a reduction in markers of inflammation and damage, suggesting that CLN helped in protecting both intestinal and liver health.

Specifically regarding liver health, the treatment with CLN appeared to help mitigate liver damage linked to the bacterial challenge. This was accomplished by influencing molecular pathways tied to immune responses and disease development in the liver. Thus, while inulin alone's effects weren’t directly isolated, the results indicate that combining it with L47 offers promising outcomes for managing inflammation and potential liver issues in livestock.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Enhances immunity
1 people found this helpful
I purchased Inulin for regular bowel movements, and it's a good prebiotic with several noted benefits. The powder is pleasant to drink, with a sweet taste. It may increase immunity, cleanse liver cells, and enhance digestion, allowing better absorption of vitamins and minerals. I recommend it.
Read More
9
Promotes digestion
It certainly works. One of my favourite dietary supplements. My intestines function like clockwork. It can be used independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits; do not doubt its effectiveness.
Read More
9
Effective supplement
It definitely works. One of my favourite dietary supplements, my intestines function like clockwork. It can be taken independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits, so do not doubt its efficacy.
Read More
9
Relieves constipation
The product is effective, no doubt about it. It works wonderfully; my intestines now function like clockwork, and I no longer suffer from constipation. It can be used independently or with food. It cleanses the liver and stimulates digestion, offering many more benefits, so do not hesitate to try it.
Read More
8
Restores liver tissue
1 people found this helpful
Inulin promotes the absorption of vital microelements like calcium, magnesium, and iron. It acts as an immunomodulator, boosting metabolic processes and endurance. It provides a sense of satiety without adding calories, lending itself as a natural coffee substitute. It benefits the immune system and has hepatoprotective properties, aiding in the restoration of damaged liver tissue, particularly helpful in treating hepatitis B and C.
Read More

Frequently Asked Questions

9
Promotes digestion
It certainly works. One of my favourite dietary supplements. My intestines function like clockwork. It can be used independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits; do not doubt its effectiveness.
9
Effective supplement
It definitely works. One of my favourite dietary supplements, my intestines function like clockwork. It can be taken independently or with food. It cleanses the liver and stimulates digestion. There are many more benefits, so do not doubt its efficacy.
8
Restores liver tissue
1 people found this helpful
Inulin promotes the absorption of vital microelements like calcium, magnesium, and iron. It acts as an immunomodulator, boosting metabolic processes and endurance. It provides a sense of satiety without adding calories, lending itself as a natural coffee substitute. It benefits the immune system and has hepatoprotective properties, aiding in the restoration of damaged liver tissue, particularly helpful in treating hepatitis B and C.
9
Relieves constipation
The product is effective, no doubt about it. It works wonderfully; my intestines now function like clockwork, and I no longer suffer from constipation. It can be used independently or with food. It cleanses the liver and stimulates digestion, offering many more benefits, so do not hesitate to try it.
8
Stimulates digestion
Excellent! Inulin works wonderfully. It helps my intestines function properly, either alone or with meals. It cleanses the liver and stimulates digestion. I find it far more beneficial than I expected; do not hesitate to try it.
7.5
Enhances immunity
1 people found this helpful
I purchased Inulin for regular bowel movements, and it's a good prebiotic with several noted benefits. The powder is pleasant to drink, with a sweet taste. It may increase immunity, cleanse liver cells, and enhance digestion, allowing better absorption of vitamins and minerals. I recommend it.
7
Detoxifies liver
1 people found this helpful
Inulin effectively cleanses the body of toxins and bad cholesterol while supporting liver and intestinal health. It is a beneficial supplement.
9
Inulin improves liver health
We explored how inulin, a prebiotic, can positively influence liver health, particularly in cases of nonalcoholic fatty liver disease (NAFLD). The study involved rats fed a high-sucrose diet, revealing that those receiving inulin showed less liver fat buildup and inflammation compared to a control group. It appeared that inulin helped restore key liver and fat metabolism markers, which play vital roles in managing fat accumulation in the liver.

Moreover, we observed that inulin supplementation improved the gut barrier function. By increasing the levels of certain proteins that help keep our gut intact, inulin seems to help prevent harmful substances from entering the body. This represents a significant advance in understanding not just the direct impact of inulin, but how gut health interconnects with liver conditions.

Our analyses of gut bacteria also yielded encouraging results. Inulin intake led to a rise in beneficial bacteria linked to short-chain fatty acid production, while harmful bacteria were decreased. This shift suggests that inulin may help create a more balanced gut environment, which is crucial for maintaining overall health. In addition to these findings, we noted changes in tryptophan metabolism that may further explain the benefits of inulin. Overall, we feel that inulin holds promise as a dietary intervention for preventing and managing NAFLD in the future.
We conducted a rigorous study to explore the effects of synbiotics on liver disease, particularly focusing on conditions known as Metabolic Dysfunction-associated Liver Disease (MASLD). This double-blind, placebo-controlled trial involved 84 patients and sought to examine how a combination of probiotics and inulin could influence liver fat accumulation, inflammation, and the gut microbiome.

Throughout the 12-week study, we aimed to assess changes in liver steatosis, which refers to fat buildup in the liver. While our findings highlighted the important role of synbiotics in reducing liver fat and inflammation, it’s crucial to note that we cannot isolate the specific effects of inulin on liver disease. The overall results showed positive outcomes in patients treated with synbiotics, including reduced liver steatosis and inflammation markers, alongside improvements in gut health.

As we look at these promising findings, we see potential for synbiotics to be a safe option for treating MASLD. However, the isolated impact of inulin alone on liver conditions requires further investigation to draw any definitive conclusions.
7
Inulin shows promise against liver injury
We explored the effects of inulin on liver disease, particularly focusing on nonalcoholic steatohepatitis (NASH) in mice with disrupted circadian rhythms. This study unearthed some fascinating insights.

Using male C57BL/6J mice, we observed that the circadian disruption significantly aggravated NASH, leading to increased levels of liver enzymes and inflammatory markers. However, treatment with inulin, alongside oat β-glucan, appeared to ease some of these adverse effects.

Inulin treatment resulted in noteworthy reductions in liver index and certain liver enzymes, suggesting it may help mitigate liver injury and inflammation. We found significant negative correlations between specific bacteria and inflammatory markers after inulin supplementation, hinting at a relationship between gut health and liver function.

Despite these promising findings, it's essential to note that inulin did not significantly affect gut microbiota diversity or cecal short-chain fatty acids. This indicates that while inulin showed some benefits in alleviating liver inflammation and damage, its overall impact on gut health wasn't as evident in this study.

In summary, while inulin exhibits potential protective effects against liver injury in the context of NASH, more research is needed to clarify its role in promoting overall gut health and addressing liver disease effectively.

References

  1. Miao J, Cui L, Zeng H, Hou M, Wang J, et al. L47 and inulin affect colon and liver inflammation in piglets challenged by enterotoxigenic through regulating gut microbiota. Front Vet Sci. 2024;11:1496893. doi:10.3389/fvets.2024.1496893
  2. Sun Y, Zhou W, Zhu M. Serum Metabolomics Uncovers the Mechanisms of Inulin in Preventing Non-Alcoholic Fatty Liver Disease. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17070895
  3. Vieira LG, de Noronha SISR, Chírico MTT, de Souza AB, de Matos NA, et al. The impact of high-fat diet consumption and inulin fiber supplementation on anxiety-related behaviors and liver oxidative status in female Wistar rats. Behav Brain Res. 2024;470:115048. doi:10.1016/j.bbr.2024.115048
  4. Mitrović M, Dobrosavljević A, Odanović O, Knežević-Ivanovski T, Kralj Đ, et al. The effects of synbiotics on the liver steatosis, inflammation, and gut microbiome of metabolic dysfunction-associated liver disease patients-randomized trial. Rom J Intern Med. 2024;62:184. doi:10.2478/rjim-2024-0004
  5. Kei N, Cheung KK, Ma KL, Yau TK, Lauw S, et al. Effects of Oat β-Glucan and Inulin on Alleviation of Nonalcoholic Steatohepatitis Aggravated by Circadian Disruption in C57BL/6J Mice. J Agric Food Chem. 2024;72:3520. doi:10.1021/acs.jafc.3c08028
  6. Liu W, Zhang L, Wei X, Xu Y, Fang Q, et al. Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo. Carbohydr Polym. 2024;327:121659. doi:10.1016/j.carbpol.2023.121659
  7. Dai X, Du Z, Jin C, Tang B, Chen X, et al. Inulin-like polysaccharide ABWW may impede CCl induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo. Carbohydr Polym. 2024;326:121637. doi:10.1016/j.carbpol.2023.121637
  8. Li JH, Liu JL, Li XW, Liu Y, Yang JZ, et al. Maternal inulin supplementation ameliorates prenatal methamphetamine exposure-induced hepatotoxicity and restores gut microbiota in mouse offspring. Ecotoxicol Environ Saf. 2024;269:115769. doi:10.1016/j.ecoenv.2023.115769
  9. Yang X, Zhang M, Liu Y, Wei F, Li X, et al. Inulin-enriched Megamonas funiformis ameliorates metabolic dysfunction-associated fatty liver disease by producing propionic acid. NPJ Biofilms Microbiomes. 2023;9:84. doi:10.1038/s41522-023-00451-y
  10. Xie G, Zhang Q, Fang Z, Che L, Lin Y, et al. Maternal Vitamin D and Inulin Supplementation in Oxidized Oil Diet Improves Growth Performance and Hepatic Innate Immunity in Offspring Mice. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12071355
  11. Wei W, Wong CC, Jia Z, Liu W, Liu C, et al. Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid. Nat Microbiol. 2023;8:1534. doi:10.1038/s41564-023-01418-7
  12. Daskova N, Heczkova M, Modos I, Hradecky J, Hudcovic T, et al. Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy. Nutrients. 2023;15. doi:10.3390/nu15020454
  13. Yang Z, Su H, Lv Y, Tao H, Jiang Y, et al. Inulin intervention attenuates hepatic steatosis in rats via modulating gut microbiota and maintaining intestinal barrier function. Food Res Int. 2023;163:112309. doi:10.1016/j.foodres.2022.112309
  14. Chen B, Shi Y, Zhang K, Chang Y, Fu P, et al. Inulin reduces liver triacylglycerol by increasing lipid droplet lipolysis in fat-loaded mice. Food Res Int. 2023;163:112226. doi:10.1016/j.foodres.2022.112226
  15. Miralles-Pérez B, Nogués MR, Sánchez-Martos V, Fortuño-Mar À, Ramos-Romero S, et al. Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet. Foods. 2022;11. doi:10.3390/foods11244072
  16. Deng P, Durham J, Liu J, Zhang X, Wang C, et al. Metabolomic, Lipidomic, Transcriptomic, and Metagenomic Analyses in Mice Exposed to PFOS and Fed Soluble and Insoluble Dietary Fibers. Environ Health Perspect. 2022;130:117003. doi:10.1289/EHP11360
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